Compressed Know-How: General Classifications Used In Microbiology

biblical angels but their true form looks like the patterns in 90s arcade carpets

Microbe masterpiece by Mehmet Berkmen and Maria Penil

CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria. (2017)

• nature url: https://nature.com/articles/nature23017 • sci-hub url: http://sci-hub.st/10.1038/nature • https://github.com/churchlab/crispr-images

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i got to work with some HeLa cells today!

as cool of an experience as this was and as interesting as these things are, it’s always important to acknowledge the bad along with the good. Henrietta Lacks’ cells revolutionized so many areas of research, but she deserved so much better.

working with these cells today just really reminded me of the duality of many scientific developments. many things have come with great cost and harm and i think that’s something important to keep in mind.

if you aren’t familiar with the story of Henrietta Lacks, i highly recommend looking her up. there’s a book about her live (the immortal life of henrietta lacks) that’s very illuminating.

A blinking for microbiology and robotics pls?

How a novel class of sulfonamides potently blocks malaria transmission

Drugs to treat malaria symptoms and insecticides to kill malaria-spreading mosquitoes have improved in recent decades, but the parasite and the mosquitoes are evolving to become resistant to these strategies.

The Baum laboratory along with colleagues at Imperial College London, UK, previously identified a new class of potent antimalarial compounds, belonging to a family of sulfonamides. These compounds kill the parasite only when it is in a specific sexual phase of its life cycle, rapidly stopping it from being able to infect a mosquito and, therefore, preventing any subsequent human infection.

In their new Disease Models & Mechanisms article, Baum and colleagues explored exactly how these compounds work, which is an essential step before the compounds can be developed for testing in patients.

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Mycena mushrooms in the moss

Watch what happens to Germs when you wash your hands with Soap at microscopic level. 🔬 The Soap molecules surround germ cells and disrupt their cell walls, causing them to burst.

Germ cells are surrounded by a cell wall that protects them from the environment. This cell wall is made up of a layer of peptidoglycan, which is a polymer of amino acids and sugars. Soap molecules are made up of two parts: a hydrophobic (water-fearing) tail and a hydrophilic (water-loving) head. When soap is added to water, the hydrophobic tails group together and the hydrophilic heads face outward, forming micelles. These micelles can surround germ cells and the hydrophobic tails can then disrupt the cell walls, causing the cells to burst.

The hydrophobic tails of the soap molecules can disrupt the cell wall in two ways. First, they can bind to the peptidoglycan molecules and weaken the bonds between them. Second, they can create holes in the cell wall. Once the cell wall is disrupted, the germ cells lose their internal contents and die.

It is important to note that soap only works to kill germ cells that are surrounded by a cell wall. Germ cells that do not have a cell wall, such as viruses, are not affected by soap.

The size of the soap micelles is important. Micelles that are too small will not be able to surround the germ cells. Micelles that are too large will not be able to penetrate the cell walls.

The concentration of soap is also important. A higher concentration of soap will be more effective at killing germ cells.

The temperature of the water can also affect the effectiveness of soap. Soap is more effective at killing germ cells in warm water than in cold water.

I hope this post has helped you understand the importance of handwashing and why doctors always ask you to do it regularly. Washing your hands with soap and water for at least 20 seconds is one of the best ways to prevent the spread of germs and stay healthy. So please, wash your hands often and help keep yourself and others safe!

Thank you for reading this post. I hope you found it informative and helpful. Please share it with your friends and family so they can learn about the importance of handwashing too. 😊🙏

this might be a stupid question, but if theres a protein that multiple organisms need, wouldn't the a t g c genetic code for it be the same for different species? or at least closely related species? so theoretically some prompts/sequences should have multiple fitting organisms or closest fitting organisms

(i know it isn't this simple, but im wondering what the exact reason it doesn't work like that is, or what im missing)

not a stupid question, i'll try to answer it to the best of my understanding, but if anyone has anything to add, please do.

put shortly: you're right! if multiple organisms need a certain protein, the code in their DNA is generally the same in that region.

from a genetics perspective, all organisms are actually extremely similar. i'm sure you've heard that we humans share more than half our genetic information with bananas and such.

this is just a factor of how evolution works. every so often, a mutation occurs in an organism's genome, which has a chance to increase the fitness of that organism, which allows it to have more offspring, which changes the mix of alleles in the population. and this is how we get different species of things.

but, because we all share a common ancestor from a long, long, long, long time ago, we do maintain some similarities, especially in regions that code for things essential to life.

those regions where things are *different* is where we're able to tell one species from another, differentiating moths from trees and such. but, overall, all living organisms have a whole lot in common.