These pictures show PAS (purple/pink) and GMS (brown/blue) staining of a lymph node biopsy from a canine patient with lymphadenopathy and weight loss. Histology was suggestive of likely a fungal organism (bright pink in the PAS stain and dark brown/black in the GMS stain), however a mixed infection with an algal species could not be definitively ruled out without microbiology.
Our microbiologist cultured an Aspergillus species from this dog, and is in the process of ruling out any other possibilities.
What's especially cool is in one of the PAS pictures, you can see an organism trapped within an actively dividing macrophage!
plasmodial slime mold consuming a Trametes fungus by Michael Harz
Microbiology!
[ID: a banner made of emojis of microscopes, bubbling flasks, and DNA, with different bacteria emojis from a combo emoji scattered between them. /End ID]
by TheMicrobiology09 on yt
This NPR interview with with Angela Saini about how race science never really left the global scientific consciousness is super interesting! I’m gonna read her book!
An innovative artificial intelligence program called CLEAN (contrastive learning–enabled enzyme annotation) has the ability to predict enzyme activities based on their amino acid sequences, even if the enzymes are unfamiliar or inadequately understood. The researchers have reported that CLEAN has surpassed the most advanced tools in terms of precision, consistency, and sensitivity. However, a deeper understanding of enzymes and their roles would be beneficial in a number of disciplines, including genetics, chemistry, pharmaceuticals, medicine, and industrial materials.
The scientists are using the protein language to forecast their performance, similar to how ChatGPT uses written language data to generate predictive phrases. Almost all scientists desire to comprehend the purpose of a protein as soon as they encounter a new protein sequence. Furthermore, this tool will aid researchers in promptly recognizing the suitable enzymes needed to manufacture chemicals and materials for various applications, be it in biology, medicine, or industry.
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– there are three types of junctions: – tight – desmosome – gap
– tight junctions seal epithelial cells to one another
– desmosomes have “spotted” seals, where keratin filaments anchor the two cells
– gap junctions have channels to allow the passage of ions and molecules
Coelastrum, a microalgae.