Panorama Of Jupiter

Studying DNA Breaks to Protect Future Space Travelers

Genes in Space logo. May 9, 2019 Earth’s atmosphere shields life on the ground from cosmic radiation that can damage DNA.  Astronauts in space have no such protection, and that puts them at risk. An investigation on the International Space Station examines DNA damage and repair in space in order to help protect the long-term health of space travelers. An organism carries all of its genetic information in its deoxyribonucleic acid or DNA. This blueprint for life takes the form of specific sequences of nitrogen bases: adenine, cytosine, guanine, and thymine, represented by the letters A, C, G and T.

Image above: The miniPCR device, used to make multiple copies of a particular strand of DNA in space. Image Credit: NASA. One type of DNA damage is double strand breaks, essentially a cut across both strands of DNA. Cells repair these breaks almost immediately, but can make errors, inserting or deleting DNA bases and creating mutations. These mutations may result in diseases such as cancer. Genes in Space-6 looks at the specific mechanism cells use to repair double strand breaks in space. The investigation takes cells of the yeast Saccharomyces cerevisiae to the space station, where astronauts cause a specific type of damage to its DNA using a genome editing tool known as CRISPR-Cas9. The astronauts allow the cells to repair this damage, then make many copies of the repaired section using a process called polymerase chain reaction (PCR) with an onboard device, the miniPCR. Another device, MinION, is then used to sequence the repaired section of DNA in those copies. Sequencing shows the exact order of the bases, revealing whether the repair restored the DNA to its original order or made errors. The investigation represents a number of firsts, including the first use of CRISPR-Cas9 genetic editing on the space station and the first time scientists evaluate the entire damage and repair process in space.

Image above: The student team that developed the Genes in Space 6 experiment. From left to right: David Li, Aarthi Vijayakumar, Michelle Sung, and Rebecca Li. Image Credit: Boeing. “The damage actually happens on the space station and the analysis also happens in space,” said one of the investigators from miniPCR Bio, Emily Gleason. “We want to understand if DNA repair methods are different in space than on Earth.” This investigation is part of the Genes in Space program. Founded by miniPCR and Boeing, the program challenges students to come up with DNA experiments in space that involve using the PCR technique and the miniPCR device on the station. Students submit ideas online, and the program chooses five finalists. These finalists are paired with a mentor scientist who helps them turn their idea into a presentation for the ISS Research and Development Conference. A panel of judges selects one proposed experiment to fly to the space station. “We want to inspire students to think like scientists and give them the opportunity for an authentic science experience that doesn’t cost them anything,” says Gleason. More than 550 student teams submitted ideas last year. The Genes in Space-6 investigation student team includes Michelle Sung, Rebecca Li, and Aarthi Vijayakumar at Mounds View High School in Arden Hills, Minnesota, and David Li, now a freshman at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts. Their mentor is Kutay Deniz Atabay at MIT.

Image above: The Genes in Space 6 student team. Image Credit: GENES IN SPACE. Other investigators include Sarah E. Stahl and Sarah Wallace with NASA’s Johnson Space Center Microbiology group in Houston; G. Guy Bushkin, Whitehead Institute for Biomedical Research, Cambridge; Melissa L. Boyer, Teresa K. Tan, Kevin D. Foley, and D. Scott Copeland at Boeing; and Ezequiel Alvarez Saavedra, Gleason, and Sebastian Kraves at Amplyus LLC, in Cambridge. Amplyus is the parent company of miniPCR Bio. “One thing the investigation will tell us is yes, we can do these things in space,” said Gleason. “We expect to see the yeast use the error-free method of repair more frequently, which is what we see on Earth; but we don’t know for sure whether it will be the same or not. Ultimately, we can use this knowledge to help protect astronauts from DNA damage caused by cosmic radiation on long voyages and to enable genome editing in space.” The procedures used in this investigation may have applications for protecting people from radiation and other hazards in remote and harsh locations on Earth as well. Related links: Genes in Space-6: https://www.nasa.gov/mission_pages/station/research/experiments/explorer/Investigation.html?#id=7893 miniPCR: https://www.minipcr.com/ MinION: https://www.nasa.gov/mission_pages/station/research/news/biomolecule_sequencer Genes in Space program: https://www.genesinspace.org/ Space Station Research and Technology: https://www.nasa.gov/mission_pages/station/research/index.html International Space Station (ISS): https://www.nasa.gov/mission_pages/station/main/index.html Images (mentioned), Text, Credits: NASA/Michael Johnson/JSC/International Space Station Program Science Office/Melissa Gaskill. Greetings, Orbiter.ch Full article

Well, money is usually made from paper.

If money did grow on trees, we’d probably be more concerned about protecting the environment.

Science gets one horsepower fast

Who Needs Hard Drives? Scientists Store Film Clip in DNA

In a first, researchers converted a movie into a DNA sequence and inserted it into bacteria. They hope to someday use the technology to record cell behavior.

It was one of the very first motion pictures ever made: a galloping mare filmed in 1878 by the British photographer Eadweard Muybridge, who was trying to learn whether horses in motion ever become truly airborne.

More than a century later, that clip has rejoined the cutting edge. It is now the first movie ever to be encoded in the DNA of a living cell, where it can be retrieved at will and multiplied indefinitely as the host divides and grows.

The advance, reported on Wednesday in the journal Nature by researchers at Harvard Medical School, is the latest and perhaps most astonishing example of the genome’s potential as a vast storage device.

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-My sun and stars!

-Moon of my life!

5 things that may surprise you about the Moon

…In honor of International Observe the Moon Night

October 28th is International Observe the Moon Night, a worldwide, public celebration of lunar science and exploration held annually since 2010 thanks to our Lunar Reconnaissance Orbiter (LRO) mission team and partners. One day each year, everyone on Earth is invited to observe and learn about the Moon together, and to celebrate the cultural and personal connections we all have with our planet’s nearest neighbor.

Here are 5 things that might surprise you about the Moon.

1. There has been a spacecraft there for 100 lunar days

In October 2017, LRO celebrates one hundred days of collecting scientific data at the Moon. One hundred Moon days. From our perspective on Earth, one lunar day is one full phase cycle, or about 29.5 Earth days. That’s 100 opportunities to observe changes from night to day, photograph the surface at different Sun angles, measure rising and falling temperatures, study the way certain chemicals react to the daily light and temperature cycle, and increase our understanding of the Moon as a dynamic place.

2. You can still see the paths left by Apollo astronauts’ boot prints and rovers

Much of the lunar surface is covered in very fine dust. When Apollo astronauts landed on the Moon, the descent stage engine disturbed the dust and produced a distinct bright halo around the lunar module. As astronauts moved around, their tracks exposed the darker soil underneath, creating distinct trails that we know, thanks to LRO, are still visible today. The Moon has no atmosphere, so there is no wind to wipe away these tracks.

3. The Moon has tattoos!

Observations from LRO show mysterious patterns of light and dark that are unique to the Moon. These lunar swirls look painted on, like the Moon got ‘inked.’ Lunar swirls, like these imaged at Reiner Gamma by LRO, are found at more than 100 locations across the lunar surface. Lunar swirls can be tens of miles across and appear in groups or as isolated features. 

Researchers think these patterns form in places where there’s still a remnant of the Moon’s magnetic field. There are still many competing theories about how swirls form, but the primary idea is that the local magnetic field deflects the energetic particles in the solar wind, so there’s not as much weathering of the surface. The magnetically shielded areas would then look brighter than everything around them.

4. There were once active volcanoes, that shaped what we see now

Early astronomers named the large dark spots that we see on the near side of the Moon “maria,” Latin for “seas,” because that’s what they thought they were. We now know that the dark spots are cooled lava, called basalt, formed from ancient volcanic eruptions. The Moon’s volcanoes are no longer active, but their past shapes the Moon that we see today. The Moon doesn’t have large volcanoes like ones in Hawaii, but it does have smaller cones and domes. 

Other small features derived from volcanic activity include rivers of dried lava flows, like the ones visible in this image of Vallis Schroteri taken by LRO, and dark areas formed from eruptive volcanoes that spewed fire. For many years, scientists thought the Moon’s volcanic activity died out long ago, but there’s some evidence for relatively “young” volcanism, suggesting that the activity gradually slowed down instead of stopping abruptly.

5. Anyone, anywhere can participate in International Observe the Moon Night.  

How to celebrate International Observe the Moon Night

Attend an event –  See where events are happening near you by visiting http://observethemoonnight.org

Host an event – Call up your neighbors and friends and head outdoors – no special equipment is needed. Let us know how you celebrated by registering your event!

Don’t let cloudy weather get you down! Observe the Moon in a variety of ways from the comfort of indoors – View stunning lunar vistas through images and videos, or explore the Moon on your own with QuickMap or Moon Trek

Join the worldwide conversation with #ObserveTheMoon on Twitter, Instagram and Facebook

For regular Moon-related facts, updates and science, follow @NASAMoon on Twitter

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

"Who is afraid of Super Woolf?"

Gene discovery unlocks mysteries to our immunity

"It's exciting to consider that C6 has existed for more than 500 million years, preserved and passed down from simple organisms all the way to humans. But only now are we gaining insights into its importance."

Australia’s national science agency CSIRO has identified a new gene that plays a critical role in regulating the body’s immune response to infection and disease.

The discovery could lead to the development of new treatments for influenza, arthritis and even cancer.

The gene, called C6orf106 or “C6”, controls the production of proteins involved in infectious diseases, cancer and diabetes. The gene has existed for 500 million years, but its potential is only now understood.

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What doesn't tear you makes you doper

Substitutional defects ( 2 ) are point defects in which an impurity atom takes the place of a native atom within the crystal lattice. Semiconductors often intentionally add substitional defects through doping, such as adding boron or phosphorous to silicon to create an n- or p-type semiconductor, and certain alloys include extraneous elements to create substitional defects for solution hardening purposes.

Image source.

On November 9, 1967, the uncrewed Apollo 4 test flight made a great ellipse around Earth as a test of the translunar motors and of the high speed entry required of a crewed flight returning from the Moon. https://go.nasa.gov/2zybcxC

Spikes of graphene can kill bacteria on implants

A tiny layer of graphene flakes becomes a deadly weapon and kills bacteria, stopping infections during procedures such as implant surgery

A tiny layer of graphene flakes becomes a deadly weapon and kills bacteria, stopping infections during procedures such as implant surgery. This is the findings of new research from Chalmers University of Technology, Sweden, recently published in the scientific journal Advanced Materials Interfaces.

Operations for surgical implants, such as hip and knee replacements or dental implants, have increased in recent years. However, in such procedures, there is always a risk of bacterial infection. In the worst case scenario, this can cause the implant to not attach to the skeleton, meaning it must be removed.

Bacteria travel around in fluids, such as blood, looking for a surface to cling on to. Once in place, they start to grow and propagate, forming a protective layer, known as a biofilm.

A research team at Chalmers has now shown that a layer of vertical graphene flakes forms a protective surface that makes it impossible for bacteria to attach. Instead, bacteria are sliced apart by the sharp graphene flakes and killed. Coating implants with a layer of graphene flakes can therefore help protect the patient against infection, eliminate the need for antibiotic treatment, and reduce the risk of implant rejection. The osseointegration – the process by which the bone structure grow to attach the implant – is not disturbed. In fact, the graphene has been shown to benefit the bone cells.

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This Brainless Slime Learns And Remembers by Slurping Stuff From Its Environment

Slime mould might easily be one of the strangest life forms on our planet. They are neither plants, animals, nor fungi, but various species of complex, single-celled amoebas of the protist kingdom. Sometimes they form colonies able to grow, move, and

Even without a nervous system, they are able to learn about substances they encounter, retaining that knowledge and even communicating it to other slime moulds.