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Hi Kate! What did you learn from your Heart Cells experiment? Sounds so interesting!

Small Tissue Chips in Space a Big Leap Forward for Research

Tissue chips, thumb-drive sized devices that contain human cells in a 3D matrix, represent a giant leap in science.

They can test cells’ response to:

•stresses

•drugs

•genetic changes

The Tissue Chips in Space initiative seeks to better understand the role of microgravity on human health and disease and to translate that understanding to improved human health on Earth.

This series of investigations to test tissue chips in microgravity aboard the International Space Station is planned through a collaboration between the National Center for Advancing Translational Sciences (NCATS) at the National Institutes for Health (NIH) and the National Laboratory in partnership with NASA.

Many of the changes in the human body caused by microgravity resemble the onset and progression of diseases associated with aging on Earth, but in space, changes occur much faster. Scientists may be able to use tissue chips in space to model changes that take months or years to happen on Earth.

A tissue chip needs three properties, according to Lucie Low, scientific program manager at NCATS. “It has to be 3D,” she explained. “It must have multiple different types of cells, and it must have microfluidic channels. Essentially, you get a functional unit of what human tissues are like, outside of the body,” said Low.

As accurate models of the structure and function of human organs, tissue chips provide a model for predicting whether a drug, vaccine or biologic agent is safe in humans more quickly and effectively than current methods.

This first phase of Tissue Chips in Space includes five investigations. An investigation of immune system aging is planned for launch on the SpaceX CRS-16 flight, scheduled for mid-November. The other four, scheduled to launch on subsequent flights, include lung host defense, the blood-brain barrier, musculoskeletal disease and kidney function. This phase tests the effects of microgravity on the tissue chips and demonstrates the capability of the automated system.

All five investigations make a second flight about 18 months later to confirm use of the model, such as testing potential drugs on the particular organs. Four more projects are scheduled for launch in summer 2020, including two on engineered heart tissue to understand cardiovascular health, one on muscle wasting and another on gut inflammation.

Ultimately, the technology could allow astronauts going into space to take along personalized chips that could be used to monitor changes in their bodies and to test possible countermeasures and therapies. That would be a major leap forward in keeping astronauts healthy on missions to deep space!

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