Blorbo Family Tree

Can a bat protein treat human inflammation?

A protein from bats shows promise for fighting inflammatory diseases in humans.

“Bats have attracted great attention as a likely reservoir of the SARS-CoV-2 virus responsible for the COVID-19 pandemic,” says Professor Wang Lin-Fa of the Duke-NUS Emerging Infectious Diseases (EID) Programme and senior author of the study in the journal Cell. “But this unique ability to host yet survive viral infections could also have a very positive impact on human health if we can understand and exploit how they achieve this.”

The research is focused on multi-protein complexes called inflammasomes that are responsible for the overactive inflammation that causes serious symptoms in many diseases. Inflammasomes are also implicated in functional decline in aging.

The researchers discovered that a bat protein called ASC2 has a powerful ability to inhibit inflammasomes, thereby limiting inflammation.

“This suggests that the high-level activity of ASC2 is a key mechanism by which bats keep inflammation under control, with implications for their long lifespan and unique status as a reservoir for viruses,” explains Matae Ahn, first author and co-corresponding author of the study and an adjunct research fellow with the EID Programme and the SingHealth Duke-NUS Medicine Academic Clinical Programme.

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Lamproderma scintillans on the edge of a leaf via andysandsphotography

When sodium hypochlorite (bleach) solution is added to luminol, a chemical reaction occurs that releases energy in the form of light. This is called chemiluminescence. The bleach solution acts as an oxidizing agent, which means it takes electrons away from the luminol molecule. This causes the luminol molecule to become excited, and it releases the energy as light.

🎥 Courtesy: Kendra Frederick

The luminol molecule is made up of two amino groups, a carbonyl group, and an azo group. The amino groups are electron-rich, while the carbonyl group is electron-poor. The azo group is a conjugated system, which means that the electrons in the double bonds can move freely from one atom to another.

When sodium hypochlorite (bleach) solution is added to luminol, the bleach molecules react with the amino groups of the luminol molecule. This reaction takes electrons away from the luminol molecule, which causes the luminol molecule to become oxidized. The oxidized luminol molecule is in an excited state, which means that it has more energy than it normally does.

The excited luminol molecule then releases the extra energy as light. This light is called chemiluminescence. The light emitted by the chemiluminescence reaction is blue because the luminol molecule has a blue fluorescence.

The chemiluminescence reaction between luminol and sodium hypochlorite is catalyzed by the presence of a metal ion, such as iron or copper. The metal ion helps to stabilize the excited state of the luminol molecule, which makes it more likely to release the extra energy as light.

The chemiluminescence reaction is very sensitive to impurities, so it is important to use pure chemicals. The reaction can also be affected by the pH of the solution. The optimal pH for the reaction is around 9.

The chemiluminescence reaction between luminol and sodium hypochlorite can be used to detect blood, as the iron in hemoglobin can catalyze the reaction. The reaction is also used in some commercial products, such as glow sticks and emergency lights.

I hope you enjoyed learning about this. ❤️🙏

Paleontologists Discover 52-Million-Year-Old Bat

The fossil represents the earliest-known species of the flying mammal

The fossil record is biased against bats. The flying mammals are small, making their fossilized remains very hard to find. And their light skeletons—ideal for flying around—mean it takes special circumstances for their bodies to be preserved. And yet, against these odds, paleontologists recently uncovered the exceptionally complete skeleton of what now stands as the earliest known bat.

To date, the most complete early bat fossils have come from an area paleontologists call Fossil Lake in Wyoming. The rock layers are world-famous for containing beautifully preserved fish, birds, mammals and other organisms that lived in the area about 52 million years ago. Among the stunning fossils recovered from these rocks, Naturalis Biodiversity Center paleontologist Tim Rietbergen and colleagues report Wednesday in PLOS One, are fossils of a new bat species the researchers have named Icaronycteris gunnelli. By comparing this new species with other early bats, paleontologists are beginning to develop a deeper understanding of how bats spread around the world in that period.

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Cribraria cancellata by Sarah Lloyd

Botox is made with botulinum toxin,, ok.

clostridium botulinum is anaerobic bacteria. form spores that release neurotoxin. cause paralysis

can be evident in honey. home canned foods. no oxygen

this months herbologist reward, the verdigris agaric! to all my amazing patrons, this little mushroom postcard print with its folklore and facts is now on its way to you!

gorgeous mold in a petri dish, Sporothrix schenckii

What advice would you give to someone who is going into microbiology ? Love your blog 😺

thank you! 🫶🏻

for someone going into microbiology, i’d definitely recommend putting effort into your chemistry courses, especially if they’re not your strong suit (i’m not very good at chemistry)

also, take any lab experiences that you can get, even if they’re not micro! any time that you can get into the lab and get your hands dirty (metaphorically speaking) will help you develop your skills!